A Symposium on Mechanisms of Toxicity by W. N. Aldridge (eds.)

By W. N. Aldridge (eds.)

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The time course of inhibition of the enzyme activity toward benzylamine is also shown <•>· Monoamine Oxidase Inhibitors 23 0·12 ""'· ............ ~. ___ ----· OL-------------~5~------------~10~----------~15° Time (min) FIG. 7. Non-enzymic reaction of ,8-phenylethylhydrazine with phenylacetaldehyde. M ,8-phenylethylhydrazine. Hydrazone formation was measured at 235 nm ( 0) and the ability of the product to inhibit the oxidation of benzylamine by monoamine oxidase is shown (e). change in extinction during the reaction of ,8-phenylethylhydrazine with monoamine oxidase indicate that only negligible quantities of the free aldehyde are produced during the reaction, implying that the rate of hydrazone formation in the presence of the enzyme is greater than the rate of the condensation of aldehyde and hydrazine in its absence.

Ges. , 312, 1 WERNER, G. & KUPERMAN, A. S. (1963). In Handbuch der Experimentellen Pharmakologie, vol. 15, ed. Koelle, G. , pp. 57Q-678. Berlin: Springer Verlag WoLTHUIS, 0. L. & MEETER, E. (1968). Eur. J. , 2, 387 ZETLER, G. (1968). Int. J. , 7, 325 STELTER, W. MECHANISM OF INHIBITION OF GLUTAMINE SYNTHETASE BY METHIONINE SULPHOXIMINE A. MEISTER, R. A. RONZIO, W. B. ROWE, J. D. GASS &S. L. N. RAO Department of Biochemistry, Cornell University Medical College, N. Y. Glutamine synthetase catalyses the coupled energy-requiring synthesis of glutamine from glutamate and ammonia and the energy-providing cleavage of adenosine 5'-triphosphate (ATP) to adenosine 5'-diphosphate (ADP) and inorganic phosphate (Pi) in accordance with the reaction shown in Fig.

Such stability is inconsistent with an a-N-phosphoryl or a carboxyl phosphate derivative, for such compounds are known to be very susceptible to hydrolysis. , 1969). The products 53 Glutamine Synthetase Inhibition 0·6 0·2 CAF} { AMP Q)·s £a Picrate 1--1 X 1--1 ·2·~ 0 0 0-4 0 E c: H 1--------1 Q) Q)- ::oiil 0 0 Pi 0·6 I X+ Alkaline phosphatase I 0-4 0·2 0 6 4 2 t 2 4 6 8 ~ Origin em FIG. 11. Hydrolysis of the 14 C-32P-methionine sulphoximine derivative (X) by calf intestine alkaline phosphatase.

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