ABC Proteins: From Bacteria to Man by I Barry Holland, Susan P. C. Cole, Karl Kuchler, Christopher

By I Barry Holland, Susan P. C. Cole, Karl Kuchler, Christopher F. Higgins

ABC Proteins is an in-depth, up to date research of all that's identified concerning the topic up to now. It discusses and compares evolution, biology and mechanism of motion of all recognized ABC proteins, together with the 1st structural reports in addition to medical implications. it is going to be beneficial to someone attempting to remain abreast of the newest findings. This booklet is certain to turn into a vintage and should frequently be up-to-date. Key gains* Phylogeny and Evoloution of ABC Transporters* primary features of the Mechanism of motion of ABC Transporters* Prokaryote ABC Transporters* Non-Mammalian Transporters* Multidrug Transporters* ABC Transporters, Physiological Roles and Human disorder* complete colour all through

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In: Escherichia coli and Salmonella Cellular and Molecular Biology, 2nd ed. (ed. C. Neidhardt), pp. 1175–1209. Washington: ASM Press. , Zelcer, N. and van Helvoort, A. (2000) ABC transporters in lipid transport. Biochim. Biophys. Acta 1486, 128–144. , Gilot, P. and Content, J. (2000) The ATP binding cassette (ABC) transport systems of Mycobacterium tuberculosis. FEMS Microbiol. Rev. 24, 449–467. , Luciani, M. and Chimini, G. (1999) The ABCA subclass of mammalian transporters. Biochim. Biophys. Acta 1461, 395–404.

And Goffeau, A. (1997) Complete inventory of the yeast ABC proteins. Nat. Genet. 15, 137–145. C. and Poolman, B. (2001) Peptides and ATP binding cassette peptide transporters. Res. Microbiol. 152, 245–258. , Boos, W. and Welte, W. (2000) Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis. EMBO J. 19, 5951–5961. A. L. (1993) ATPdependent transport systems in bacteria and humans – relevance to cystic fibrosis and multidrug resistance.

11, 899–910. M. A. (1991) Genetic transformation in Streptococcus pneumoniae: nucleotide sequence analysis shows comA, a gene required for competence induction, to be a member of the bacterial ATP-dependent transport protein family. J. Bacteriol. 173, 372–381. L. H. (1998) Crystal structure of the ATP-binding subunit of an ABC transporter. Nature 396, 703–707. , Dassa, E. and Schneider, E. (2000) ATP modulates subunit–subunit interactions in an ATPbinding cassette transporter (MalFGK2) determined by site-directed chemical crosslinking.

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