Anaerobiosis and stemness : an evolutionary paradigm for by Zoran Ivanovic, Marija Vlaski-Lafarge

By Zoran Ivanovic, Marija Vlaski-Lafarge

Anaerobiosis and Stemness: An evolutionary paradigm presents a context for figuring out the various complexities and evolutionary positive aspects of stem cells and the scientific implications of anaerobiosis stem cells. Combining theoretical and experimental wisdom, the authors offer a extensive knowing of the way the absence or low focus of oxygen can play an influential position within the upkeep and self-renewal of stem cells and stem phone differentiation. This knowing has medical implications for the fields of regenerative medication, melanoma biology and transplantation, in addition to mobilephone engineering and mobile treatment. Anaerobiosis and Stemness is a crucial source for stem mobilephone and developmental biologists alike, in addition to oncologists, melanoma biologists, and researchers utilizing stem cells for regeneration.

  • Highlights the molecular and evolutionary beneficial properties of stem cells which lead them to so vital to all organic research
  • Explores tools of isolation, characterization, activation, and upkeep of stem cells
  • Includes versions for scientific program in regenerative drugs, melanoma remedy, and transplantation

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Extra resources for Anaerobiosis and stemness : an evolutionary paradigm for therapeutic applications

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25] Carreau A, El Hafny-Rahbi B, Matejuk A, Grillon C, Kieda C. Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia. J Cell Mol Med 2011;15:1239–53. [26] Gleadle J, Ratcliffe PJ. Hypoxia. In: Encyclopedia of life sciences. Chichester: John Wiley and Sons, Ltd; 2001. 34 Anaerobiosis and Stemness [27] Gnaiger E. Oxygen conformance of cellular respiration. A perspective of mitochondrial physiology. Adv Exp Med Biol 2003;543:39–55. [28] Schofield R.

Histochem Cell Biol 2007;128:253–61. [93] Mohyeldin A, Garzón-Muvdi T, Quiñones-Hinojosa A. Oxygen in stem cell biology: a critical component of the stem cell niche. Cell Stem Cell 2010;7:150–61. [94] Perry JM, Li L. To be or not to be a stem cell: dissection of cellular and molecular components of haematopoietic stem cell niches. EMBO J 2012;31:1060–1. 4 What Can We Learn? 1 First Notions of Oxygenation Ex Vivo More than one century ago, Alexis Carrel reported the results of experiments aimed to maintain ex vivo tissue of chicken embryo and fetal connective tissue, heart tissue, and ­portal vein tissue as well as the Rous sarcoma cells [1].

The hematopoietic stem cell in its place. Nat Immunol 2006;7:333–7. [45] Nombela-Arrieta C, Pivarnik G, Winkel B, Canty KJ, Harley B, Mahoney JE. Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment. Nat Cell Biol 2013;15:533–43. The “Hypoxic” Stem Cell Niche 35 [46] Kunisaki Y, Bruns I, Scheiermann C, Ahmed J, Pinho S, Zhang D, et al. Arteriolar niches maintain haematopoietic stem cell quiescence. Nature 2013;502:637–43.

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