Analytical Biochemistry by David Holme, Hazel Peck

By David Holme, Hazel Peck

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In some of the organisms there is an increase in chitin and a shift from ß- to a-glucans in the cell wall. Human infection by these organisms is common in their endemic areas. Approximately 40 million people have, or have had, histoplasmosis in the Ohio and Mississippi valleys of the United States. The number infected by Coccidioides is almost as great. However, most infections are completely symptomless, and fully 99% resolve spontaneously. One is left with a strong specific immunity to reinfection and is skin test-positive.

This time the common ingredient was cottonseed meal. Following the groundnut meal studies, scientists successfully isolated aflatoxins from the cottonseed meal and concluded that the two outbreaks were aflatoxicoses. Halver (1965) presented a thorough review of the trout hepatoma outbreaks. III. MYCOTOXIN-PRODUCING CONIDIAL FUNGI A. Initial Considerations In the past 20 yr, numerous conidial fungi have been implicated in the production of mycotoxins and mycotoxicoses. Species of Aspergillus, Pénicillium, and Fusarium have been involved most frequently, but several other genera have also been identified as toxin producers.

Rather, they produced xanthomegnin and viomellein which, when administered to mice, produced symptoms identical to those produced by feeds experimentally inoculated with the Indiana isolates. Thus xanthomegnin and 46 Philip B. Mislivec viomellein were implicated as the mycotoxins. All the Indiana isolates produced a strong, musty odor. This point is made because a recent report on nine P. viridicatum isolates (Stack and Mislivec, 1978) showed that only three of the isolates had a musty odor, and that all three produced xanthomegnin and viomellein but no ochratoxin A or citrinin.

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