Antibodies, Antigens, and Molecular Mimicry by John J. Langone (Eds.)

By John J. Langone (Eds.)

The significantly acclaimed laboratory regular, Methods in Enzymology, is without doubt one of the so much hugely revered guides within the box of biochemistry. considering the fact that 1955, each one quantity has been eagerly awaited, often consulted, and praised through researchers and reviewers alike. The sequence includes a lot fabric nonetheless appropriate this day - really an important book for researchers in all fields of lifestyles sciences

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I47 R. J. Polljak, L. M. Amzel, H. P. Avey, B. L. Chen, R. P. Phizackerley, and F. San, Nature (London) 245, 165 (1973). 148 E. A. Padlan, D. Segal, T. F. Spande, and D. R. Davies, Proc. Natl. Acad. Sci. A. 69, 3689 (1972). ~49j. UrbaJn, M. Wikler, J. D. Franssen, and C. Collignon, Proc. Natl. Acad. Sci. A. 74, 5126 (1977). ~50R. C. Kennedy, J. L. Melnick, and D. R. Dreesman, Science 223, 930 (1984). 151 Looking back to early experiments on autoanti-idiotypic antibodies, 7 internal images appear not to be found among such autoanti-idiotypic antibodies.

J. W. Morrow and D. A. Isenberg, "Autoimmune Rheumatic Disease," Blackwell Scientific Publications, Oxford, 1987. b In vitro experiments conducted in murine systems. c Experiments conducted on human cells in vitro. a In vivo experiments conducted in rodent systems. • Human therapy. Molecular Mimicry and Receptors Owing to the e n o r m o u s variability in the antibody population, it m a y be possible that a m o n g all the different antibodies a few antibodies which are p r o d u c e d m a y recognize a h o r m o n e in a fashion that mimics the way a physiological r e c e p t o r recognizes the hormone.

J. P. Teeuwsen, C. J. Siebelink, M. J. Stukcert, A. G. C. M. UytdeHaag, and A. D. M. E. , Int. Conf. AIDS, 4th Book 2, p. 71 (1988). 59 S. Miiller, W. J. W. Morrow, L. Wing, and H. Kfhler, unpublished data (1988). 6o W. J. W. Morrow, I. Gaston, T. Anderson, K. Steimer, and M. S. McGrath, J. Virol (submitted for publication). 61 K. Stein and J. Soderstrom, J. Exp. Med. 160, 1001 (1984). 62 K. E. Stein, Curr. Top. Microbiol. lmmunol. 57 (1985). 63 W. Lee, H. Cosenza, and H. K6hler, Nature (London) 247, 55 (1974).

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