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Extra info for Antibodies, Antigens, and Molecular Mimicry
I47 R. J. Polljak, L. M. Amzel, H. P. Avey, B. L. Chen, R. P. Phizackerley, and F. San, Nature (London) 245, 165 (1973). 148 E. A. Padlan, D. Segal, T. F. Spande, and D. R. Davies, Proc. Natl. Acad. Sci. A. 69, 3689 (1972). ~49j. UrbaJn, M. Wikler, J. D. Franssen, and C. Collignon, Proc. Natl. Acad. Sci. A. 74, 5126 (1977). ~50R. C. Kennedy, J. L. Melnick, and D. R. Dreesman, Science 223, 930 (1984). 151 Looking back to early experiments on autoanti-idiotypic antibodies, 7 internal images appear not to be found among such autoanti-idiotypic antibodies.
J. W. Morrow and D. A. Isenberg, "Autoimmune Rheumatic Disease," Blackwell Scientific Publications, Oxford, 1987. b In vitro experiments conducted in murine systems. c Experiments conducted on human cells in vitro. a In vivo experiments conducted in rodent systems. • Human therapy. Molecular Mimicry and Receptors Owing to the e n o r m o u s variability in the antibody population, it m a y be possible that a m o n g all the different antibodies a few antibodies which are p r o d u c e d m a y recognize a h o r m o n e in a fashion that mimics the way a physiological r e c e p t o r recognizes the hormone.
J. P. Teeuwsen, C. J. Siebelink, M. J. Stukcert, A. G. C. M. UytdeHaag, and A. D. M. E. , Int. Conf. AIDS, 4th Book 2, p. 71 (1988). 59 S. Miiller, W. J. W. Morrow, L. Wing, and H. Kfhler, unpublished data (1988). 6o W. J. W. Morrow, I. Gaston, T. Anderson, K. Steimer, and M. S. McGrath, J. Virol (submitted for publication). 61 K. Stein and J. Soderstrom, J. Exp. Med. 160, 1001 (1984). 62 K. E. Stein, Curr. Top. Microbiol. lmmunol. 57 (1985). 63 W. Lee, H. Cosenza, and H. K6hler, Nature (London) 247, 55 (1974).