By W. G. Robertson (auth.), B. E. C. Nordin (eds.)
Calcium in Human Biology presents an authoritative assessment of present wisdom and issues how one can additional growth within the figuring out of this crucial nutrient. as well as contemplating the tested significance of an sufficient nutritional resource of accessible calcium for the formation of sound bones and enamel, there's distinct dialogue of the half calcium performs in a number of features of human metabolism. The booklet is written basically for these operating within the dietary sciences and similar fields. it is going to even be of curiosity to clinicians, nutritionists, and to these extra usually within the organic sciences, in addition to to these within the very important sectors of the foodstuff which utilise or produce dairy items and different meals major to the provision of nutritional calcium.
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Extra resources for Calcium in Human Biology
Academic Press, New York, pp 145-173 Pressman BC (1976) Biological applications of ionophores. Annu Rev Biochem 45:501-530 Price PA, Otsuka AS, Poser JW, Kristaponis J, Ramans N (1976) Characterization of a ycarboxyglutamic acid-containing protein from bone. Proc Natl Acad Sci USA 73:1447-1451 Raaflaub J (1951) Uber ein photometriches Verfahren zur Bestimmung des ionisierten Calciums. Z Physiol Chern 288:228-233 Raaflaub J (1962) Zur photometrichen Bestimmung des ionisierten Calciums in biologischen FIUssigkeiten, insbesondere in Ham.
On each molecule of DBP there is one vitamin D-specific binding site. 4 X 10- 7 M) (Haddad and Walgate 1976b). Because of the high concentration of DBP in plasma (1-2 x 10- 6 M) no more than 10% of the available binding sites contain vitamin D or its metabolites. The function of the excess binding capacity is unknown. Apart from showing genetic polymorphism, DBP has a number of other Calcium-Regulating Hormones: Vitamin D 33 curious features. It is synthesized in the liver and the synthesis rate increases during pregnancy and under the influence of oral contraceptives (Haddad et al.
This metabolic change gives the molecule properties similar to those of the classical steroid hormones (Kodicek 1974). Hence vitamin D is now regarded as a precursor for a steroid hormone which acts in the regulation of whole-body calcium homeostasis. In this way its presence allows normal bone growth, and conversely, when it is absent, calcium homeostasis fails, leading to the bone defects of rickets or osteomalacia. However, even this description of vitamin D function now appears to be too restrictive.