Cancer Virus: The discovery of the Epstein-Barr Virus by Dorothy H. Crawford

By Dorothy H. Crawford

The Epstein-Barr virus (EBV) used to be came upon in 1964. on the time, the very concept of a plague underlying a melanoma was once innovative. melanoma is, finally, now not catching. Even now, the assumption of a virulent disease inflicting melanoma surprises many folks. yet Epstein-Barr, named after its discoverers, Sir Anthony Epstein and Dr Yvonne Barr, is attention-grabbing for different purposes too. nearly all people consists of it, but it is just below yes situations that it produces disorder. it's been linked to various, it seems that unrelated, illnesses in several populations: Burkitt's Lymphoma, generating tumors within the jaw, in African kids; a nasal tumor in China; glandular fever in Europe and the us; and nearly all of instances of Hodgkin's ailment all over.

This e-book tells the tale of the invention of the virus, and the popularity of its reference to those a number of ailments -- an account that spans the area and consists of a few awesome characters and person tales.

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Clearly, if a virus kills the cells it infects it could not cause them to grow into a tumour and so the life cycle of tumour-causing viruses must be very different. We now know that certain RNA and DNA viruses can cause tumours, but identifying them and elucidating the tumourigenic mechanisms they employ took many years. In the late nineteenth century Louis Pasteur, working in Paris, France, showed that microscopic living organisms in the air could spread infections, while at around the same time Robert Koch from Berlin, Germany, isolated the first bacterium—Bacillus anthracis, the cause of anthrax.

Dalldorf and colleagues had published a report on Burkitt Lymphoma in Kenya in 1964 in which they suggested an alternative theory to explain the geographical restriction of the tumour. 16 After all, the parasite that causes the most severe type of malaria, Plasmodium falciparum, is spread by mosquitoes that require high temperature and rainfall for their breeding cycle. They noted that: ‘In tropical Africa and New Guinea, the two regions in which this particular form of lymphoma is known to be conspicuously common, an exceptional form of malaria is also prevalent.

So Hutkin had seroconverted to EBV, either sometime before or during an attack of infectious mononucleosis. Furthermore, Diehl recalls that whereas in January her lymphocytes showed no signs of spontaneous transformation, now they ‘grew in culture like crazy’. This rapid, outgrowth of cell lines from the blood of people with infectious mononucleosis was similar to that recently noted by Pope40 and the findings from Hutkin’s blood now gave a possible explanation.

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