Chemokine Biology - Basic Research and Clinical Application: by Bernhard Moser (Editor), Gordon L. Letts (Editor), Kuldeep

By Bernhard Moser (Editor), Gordon L. Letts (Editor), Kuldeep Neote (Editor)

Chemokines play an immense function in recruiting inflammatory cells into tissues in keeping with an infection and irritation. in addition they play a major position in coordinating the circulation of T-cells, B-cells and dentritic cells, essential to generate an immune reaction (response to harm, allergens, antigens, invading microorganisms). They selectively allure leukocytes to inflammatory foci, inducing either cellphone migration and activation. they're inquisitive about a variety of ailments, like atherosclerosis, lung and pores and skin irritation, a number of sclerosis, or HIV.Volume 1 of this two-volume set discusses the immunobiology of chemokines. it's divided into elements: a) mobile goals in innate and adaptive immunity, and b) effector cellphone traffic-unrelated capabilities. including quantity 2, which discusses the pathophysiology of chemokines, either volumes provide a accomplished evaluation of chemokine biology.  

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Additional resources for Chemokine Biology - Basic Research and Clinical Application: Vol. 1: Immunobiology of Chemokines (Progress in Inflammation Research)

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Eur J Immunol 32: 837–847 Lanzavecchia A, Sallusto F (2002) Progressive differentiation and selection of the fittest in the immune response. Nat Rev Immunol 2: 982–987 Schaerli P, Loetscher P, Moser B (2001) Cutting edge: induction of follicular homing precedes effector Th cell development. J Immunol 167: 6082–6086 Ansel KM, McHeyzer-Williams LJ, Ngo VN, McHeyzer-Williams MG, Cyster JG (1999) In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines.

Th1 and Th2 T cells Naïve T cells differentiate to effector cells in lymphoid organs, such as spleen, LNs and Peyer’s patches (PPs). However, the principal sites where T helper (Th) cells and cytotoxic T cells exert their function are peripheral tissues, where pathogens are frequently encountered. Thus, effector cells up-regulate receptors for inflammationinduced endothelial adhesion molecules and inflammatory chemokines [33, 34]. Different pathogens require different effector responses, produced upon antigenrecognition by distinct T cell subsets.

Agace1 and Bernhard Homey2 1Immunology Section, Lund University, BMC I-13, 22184 Lund, Sweden; 2Department of Dermatology, Heinrich-Heine-University, Duesseldorf, Germany Introduction Epithelial tissues represent the interface between the environment and the host. They are subject to continuous insults that include mechanical injury, ultraviolet (UV) irradiation, chemicals and microbes. The integrity of the host critically depends on the adequate protection against these hazardous events. During evolution epithelial tissues developed specialised immunological structures such as mucosa-associated lymphoid tissues (MALT) or skin-associated lymphoid tissues (SALT) which together with patrolling leukocyte subsets work as sentinels at the inner and outer surface of the human body.

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