Ciba Foundation Symposium 146 - Photosensitizing Compounds:

Sure natural compounds can turn into poisonous to organic tissue while activated by way of mild. Many scientific purposes of this influence were studied over the last two decades, and This symposium brings jointly chemists, biologists, and clinicians to debate the elemental chemistry of the sensitizing compounds, their organic results, and medical purposes in remedies of assorted cancers and pores and skin problems.


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Additional info for Ciba Foundation Symposium 146 - Photosensitizing Compounds: Their Chemistry, Biology and Clinical Use

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In urinary bladder, for example, one must compare normal urothelium with the tumours. Dougherty But the principle is right. We need some selection process for sensitizers before clinical application. This provides a good clue. Jori: What determines selectivity? Some closely related structures show very different selectivities according to this analysis. Berenbaurn: We think this is mainly a question of localization. 56 respectively) and their other photophysical properties are similar (Bonnett et al 1987, Berenbaum & Bonnett 1989).

Disulphonated ZnPcS is the most active photosensitizer in this series, and the symmetric tetrasulphonated ZnPcS, prepared by the condensation method, shows no activity (at a dose of < 12 mg/kg). The corresponding disulphonated GaPcS2 and AIPcS2 show activities comparable to HpD at similar dose levels. Thus, based on the elevated in vitro activities, the desired in vivo PDT effect requires the administration of higher than expected doses of Pc dyes. We shall require a more detailed understanding of the structure-activity relationships of substituted Pcs and Ncs and their interaction with cellular components to fully exploit their potential in photodynamic therapy of cancer.

Part XX. Further investigations on tetrabenzporphin and allied substances. J Chem SOC2975-2987 McCubbin I, Phillips D 1986 The photophysics and photostability of zinc(1I) and aluminium(II1) sulphonated naphthalocyanines. J Photochem 34: 187- 195 Milanesi C, Biolo R, Reddi E, Jori G 1987 Ultrastructural studies on the mechanism of the photodynamic therapy of tumors. Photochem Photobiol 46:675-681 Moser FH, Thomas AL 1983 The phthalocyanines. Vol I and 11. CRC Press, Boca Raton, Florida Ohno T, Kato S, Yamada A, Tanno T 1983 Electron transfer reactions of the photoexcited triplet state of chloroaluminium phthalocyanine with aromatic amines, benzoquinones, and coordination compounds of iron(I1) and iron(II1).

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