Cilia and Nervous System Development and Function by Sigrid Hoyer-Fender (auth.), Kerry L. Tucker, Tamara Caspary

By Sigrid Hoyer-Fender (auth.), Kerry L. Tucker, Tamara Caspary (eds.)

Cilia are tiny microtubule-based organelles projecting from the plasma membrane of virtually all cells within the physique. some time past 10 years a flurry of analysis has indicated a vital function of this long-neglected organelle within the improvement and serve as of the relevant frightened procedure. a standard subject matter of those stories is the serious dependency of sign transduction of the Sonic hedgehog, and extra lately, Wnt signaling pathways upon cilia to manage destiny judgements and morphogenesis. either basic and motile cilia additionally play an important roles within the functionality of the anxious approach, together with the first processing of sensory info, the keep watch over of physique mass, and better capabilities similar to habit and cognition, serving as "antennae" for neurons to experience and strategy their atmosphere. during this publication we describe the constitution and serve as of cilia and many of the tissues in the course of the mind and spinal twine which are based upon cilia for his or her right improvement and function.

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2005; Dawe et al. 2007b). A link between the apical actin cytoskeleton and the basal body is provided by meckelin (also named MKS3) that interacts with the actin-binding protein filamin A, and loss of filamin A causes defects in basal body positioning and ciliogenesis (Adams et al. 2012). As a modulator of ciliary length control, the light chain subunit of cytoplasmic dynein Tctex-1 (or DYNLT1) was identified. Depletion of Tctex-1 as well as suppression of dynein heavy chain-2 (DHC2) resulted in longer cilia (Palmer et al.

The subdistal appendages of the mother centriole occur in varying numbers, but often two or three are seen in the same cross-sectional plane. Each subdistal appendage makes contact at its base with two adjacent microtubule triplets of the centriole. Likewise, the basal body of primary cilia usually possesses more than one basal foot alongside its centriolar wall (Hagiwara et al. 2002; Odor and Blandau 1985). Fig. 15 (a) Transverse section through the basal region of a primary cilium shaft of 3T6 fibroblasts showing typical 9+0 organization.

The single basal foot projects laterally from the basal body and points into the direction of ciliary beating stroke (Boisvieux-Ulrich and Sandoz 1991). Since motile cilia function to propel cells and fluids over the epithelial surface their orchestrating beating is essential for efficient flow direction. In the brain ependyma it has been shown that basal bodies first dock apically with random orientation and then reorient in a common direction. Reorientation depends on hydrodynamic forces and the planar cell polarity (PCP) protein Vangl2 (Guirao et al.

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