By Zbigniew J. Witczak
Lays the basis for brand new equipment and functions of carbohydrate click on chemistry
Introduced by way of okay. Barry Sharpless of The Scripps examine Institute in 2001, click on chemistry mimics nature, giving researchers the instruments had to generate new components speedy and reliably by means of becoming a member of small devices jointly. With contributions from greater than thirty pioneering researchers within the box, this article explores the various promising functions of click on chemistry in glycoscience. Readers will research either the fundamental suggestions of carbohydrate click on chemistry in addition to its many biomedical functions, together with man made antigens, analogs of cell-surface receptors, immobilized enzymes, particular drug supply platforms, and multivalent melanoma vaccines.
Click Chemistry in Glycoscience examines a extensive variety of methodologies and techniques that experience emerged from this quickly evolving box. each one bankruptcy describes new methods, rules, results, and purposes caused by the creation of click on tactics. Divided into 4 sections, the publication covers:
- Click chemistry techniques and decoupling
- Thio-click chemistry of carbohydrates
- Carbohydrate click on chemistry for novel man made targets
- Carbohydrate click on chemistry in biomedical sciences
Thoroughly researched, the publication displays the latest findings released within the literature. Diagrams and figures during the ebook let readers to extra simply seize complicated innovations and response procedures. on the finish of every bankruptcy, references bring about the first literature for additional research of person subject matters.
The software of click on chemistry to carbohydrates has great implications for learn. With this booklet as their advisor, researchers have a pretty good beginning from which they could increase new equipment and purposes of carbohydrate click on chemistry, together with new carbohydrate-based therapeutics.Content:
Chapter 1 Paradigm and benefit of Carbohydrate click on Chemistry technique for destiny Decoupling (pages 1–30): Roman Bielski and Zbigniew J. Witczak
Chapter 2 Thio?Click Chemistry in Glycoscience: evaluation and views (pages 31–43): Zbigniew J. Witczak
Chapter three Free?Radical Thiol?Ene and Thiol?Yne Couplings as click on strategies for Glycoconjugation (pages 45–75): Alessandro Dondoni and Alberto Marra
Chapter four the improvement and alertness of Clickable Lipid Analogs for Elucidating and Harnessing Lipid services (pages 77–105): Michael D. Best
Chapter five Clicking Sugars onto Sugars: Oligosaccharide Analogs and Glycoclusters on Carbohydrate Scaffolds (pages 107–142): Maria Laura Uhrig and Jose Kovensky
Chapter 6 click on Multivalent Glycomaterials: Glycoclusters, Glycodendrimers, Glycopolymers, Hybrid Glycomaterials, and Glycosurfaces (pages 143–182): Carmen Ortiz Mellet, Alejandro Mendez?Ardoy and Jose Manuel Garcia Fernandez
Chapter 7 towards Imaging Glycotools through click on Coupling (pages 183–210): Yves Chapleur, Christine Vala, Francoise Chretien and Sandrine Lamande?Langle
Chapter eight Bioorthogonal Reactions for Labeling Glycoconjugates (pages 211–233): Frederic Friscourt and Geert?Jan Boons
Chapter nine “Sweet” Sucrose Macrocycles through a “Click Chemistry” direction (pages 235–250): Mykhaylo A. Potopnyk and Slawomir Jarosz
Chapter 10 Neoglycoprotein Synthesis utilizing the Copper?Catalyzed Azide–Alkyne click on response and local Chemical Ligation (pages 251–270): Joanna M. Wojnar, Dong Jun Lee, Clive W. Evans, Kalyaneswar Mandal, Stephen B. H. Kent and Margaret A. Brimble
Chapter eleven Biomedical purposes of “Click”?Modified Cyclodextrins (pages 271–292): Zhenshan Jia, Rakesh okay. Singh and Dong Wang
Chapter 12 Triazolyl Glycoconjugates in Medicinal Chemistry (pages 293–323): Rama Pati Tripathi, Pratibha Dwivedi, Anindra Sharma, Divya Kushwaha and Vinod Kumar Tiwari
Chapter thirteen click on Chemistry utilized to Carbohydrate?Based Drug Discovery (pages 325–357): Vanessa Leiria Campo and Ivone Carvalho
Read Online or Download Click Chemistry in Glycoscience: New Developments and Strategies PDF
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Extra resources for Click Chemistry in Glycoscience: New Developments and Strategies
12 PARADIGM AND ADVANTAGE OF CARBOHYDRATE CLICK CHEMISTRY n a O n O n b O O O O OH O O O OH HO HO O O S OH S S O O l O O S c O l S m O O d e O O OH O S S O O l O O S m O O b l O S m O O O O OH O O HO HO >LCST O OH O O O S OH 18). The method was applied to the solid state synthesis of oligosaccharides (Fig. 19). At this point, it is impossible to say if the same decoupling can be applied to a propargyl group in which one of the hydrogen atoms (in either of the two possible positions) was replaced with a large (macromolecular) substituent. 20 PARADIGM AND ADVANTAGE OF CARBOHYDRATE CLICK CHEMISTRY O O I HN HO O O OH N O I HN O O DMTrO DMTrCl Pyr, DMAP OH I HN N Br N O O HO 1. NaOH, PhH 2. 3% TFA, CHCl 3 O O CuI/Pd(0), DMF O O NH2 HN O O O O P O P O P O O OH OH N H N O HO 1. REFERENCES 29 5. Wilkinson, B. ; Houston, T. -A. Click Chemistry in Carbohydrate Based Drug Development and Glycobiology. In Drug Design Research Perspective; Kaplan, S. ; Nova Science Publishers: New York, 2007; pp 57–102. 6. ; Lucas, R. Polymers 2011, 3, 1607–1651. 7. ; Becer, C. ; Schubert, U. S. Chem. Soc. Rev. 2012, 41, 176–191. 8. Kolb, H. ; Finn, M. ; Sharpless, K. B. Angew. Chem. Int. Ed. 2001, 40, 2004–2021. 9. Torne, C. ; Meldal, M. J. Org. Chem. 2002, 67, 3057–3064. 10. Rostovtsev, V.
18). The method was applied to the solid state synthesis of oligosaccharides (Fig. 19). At this point, it is impossible to say if the same decoupling can be applied to a propargyl group in which one of the hydrogen atoms (in either of the two possible positions) was replaced with a large (macromolecular) substituent. 20 PARADIGM AND ADVANTAGE OF CARBOHYDRATE CLICK CHEMISTRY O O I HN HO O O OH N O I HN O O DMTrO DMTrCl Pyr, DMAP OH I HN N Br N O O HO 1. NaOH, PhH 2. 3% TFA, CHCl 3 O O CuI/Pd(0), DMF O O NH2 HN O O O O P O P O P O O OH OH N H N O HO 1.
REFERENCES 29 5. Wilkinson, B. ; Houston, T. -A. Click Chemistry in Carbohydrate Based Drug Development and Glycobiology. In Drug Design Research Perspective; Kaplan, S. ; Nova Science Publishers: New York, 2007; pp 57–102. 6. ; Lucas, R. Polymers 2011, 3, 1607–1651. 7. ; Becer, C. ; Schubert, U. S. Chem. Soc. Rev. 2012, 41, 176–191. 8. Kolb, H. ; Finn, M. ; Sharpless, K. B. Angew. Chem. Int. Ed. 2001, 40, 2004–2021. 9. Torne, C. ; Meldal, M. J. Org. Chem. 2002, 67, 3057–3064. 10. Rostovtsev, V.