Control of Messenger RNA Stability by Joel G. Belasco, George Brawerman

By Joel G. Belasco, George Brawerman

This can be the 1st entire evaluation of mRNA balance and its implications for law of gene expression. Written by way of specialists within the box, Control of Messenger RNA Stability serves either as a reference for experts in legislation of mRNA balance and as a basic advent for a broader group of scientists.

  • Provides views from either prokaryotic and eukaryotic systems
  • Offers a well timed, entire evaluation of mRNA degradation, its legislation, and its importance within the keep an eye on of gene expression
  • Discusses the mechanisms, RNA structural determinants, and mobile elements that regulate mRNA degradation
  • Evaluates experimental tactics for learning mRNA degradation

Show description

Read Online or Download Control of Messenger RNA Stability PDF

Similar developmental biology books

Information Theory of Molecular Systems

In addition to offering a unified outlook on physics, details idea (IT) has a variety of purposes in chemistry and biology as a result of its skill to supply a degree of the entropy/information contained inside chance distributions and standards in their info "distance" (similarity) and independence.

The Evolution of Individuality

"This is the main stimulating publication approximately evolution i've got learn for a very long time. "--JOHN MAYNARD SMITH, The collage of Sussex `Leo Buss's principles are virtually completely new and particularly very important. in my opinion this e-book might be a milestone within the learn of evolution. "-JOHN TYLER BONNER, Princeton college Leo Buss expounds a normal concept of improvement via an easy hierarchical extension of the bogus conception of evolution.

The Origins of Larvae

Many organic evidence are irreconcilable with the idea that larvae and adults advanced from an identical genetic inventory. the writer of this ebook attracts cognizance to those, and offers his substitute speculation that larvae were transferred from one taxon to a different. In his earlier booklet (Larvae and Evolution, 1992), the writer used larval move to give an explanation for developmental anomalies in 8 animal phyla.

The Centrosome in Cell Replication and Early Development

Centrosomes play an vital position within the progress of cells and the last word improvement of many animals, and occasionally crops. as well as the traditional progress of cells, centrosomes may also play a key position within the unfold of melanoma and are of elevated curiosity to either the genetics and oncology groups.

Additional resources for Control of Messenger RNA Stability

Example text

While for some messages an initial event in the 5' region (or at the 5' end) may be the rate-determining step in decay and this event is blocked or at least slowed by RNA secondary structure (ompA, gene 32), protein binding (XpLperhaps), or ribosome stalling (ermA, ermC), the initiation of decay at alternative sites in other messages could negate the effect of a 5' stabi­ lizer. Initiation of decay by E. coli RNase III cleavage in a leader region is thought to be the mechanism for the control of mRNA stability of three opérons (Régnier and Grunberg-Manago, 1990).

F. DiMari and D. H. Bechhofer, unpublished). These findings suggest that the ability of a 5' region to function as a 5' stabilizer is dependent on the susceptibility of the downstream sequences to alternative decay initiation events and that inspection of the 5' region is not an obligatory step in the initiation of decay. While for some messages an initial event in the 5' region (or at the 5' end) may be the rate-determining step in decay and this event is blocked or at least slowed by RNA secondary structure (ompA, gene 32), protein binding (XpLperhaps), or ribosome stalling (ermA, ermC), the initiation of decay at alternative sites in other messages could negate the effect of a 5' stabi­ lizer.

The only scope for modulation of mRNA stability by the 3' end is to alter its accessibility to exonuclease digestion. This could be achieved by endonuclease cleavage of the 3' stem-loop, by alternate folding of the mRNA, or potentially by altering interactions of the stem-loop with binding proteins. While such events occur, none are known to be regulated in response to specific signals. Instead, the few regulatory events that have been studied involve rate-determining endonucleolytic cleavages controlled by the 5' end of the message (Melefors and vonGabain, 1988; Emory and Belasco, 1990), and this seems likely to be the main site at which regulation of mRNA stability occurs.

Download PDF sample

Rated 4.32 of 5 – based on 39 votes