By Joel G. Belasco, George Brawerman
This can be the 1st entire evaluation of mRNA balance and its implications for law of gene expression. Written by way of specialists within the box, Control of Messenger RNA Stability serves either as a reference for experts in legislation of mRNA balance and as a basic advent for a broader group of scientists.
- Provides views from either prokaryotic and eukaryotic systems
- Offers a well timed, entire evaluation of mRNA degradation, its legislation, and its importance within the keep an eye on of gene expression
- Discusses the mechanisms, RNA structural determinants, and mobile elements that regulate mRNA degradation
- Evaluates experimental tactics for learning mRNA degradation
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Additional resources for Control of Messenger RNA Stability
While for some messages an initial event in the 5' region (or at the 5' end) may be the rate-determining step in decay and this event is blocked or at least slowed by RNA secondary structure (ompA, gene 32), protein binding (XpLperhaps), or ribosome stalling (ermA, ermC), the initiation of decay at alternative sites in other messages could negate the effect of a 5' stabi lizer. Initiation of decay by E. coli RNase III cleavage in a leader region is thought to be the mechanism for the control of mRNA stability of three opérons (Régnier and Grunberg-Manago, 1990).
F. DiMari and D. H. Bechhofer, unpublished). These findings suggest that the ability of a 5' region to function as a 5' stabilizer is dependent on the susceptibility of the downstream sequences to alternative decay initiation events and that inspection of the 5' region is not an obligatory step in the initiation of decay. While for some messages an initial event in the 5' region (or at the 5' end) may be the rate-determining step in decay and this event is blocked or at least slowed by RNA secondary structure (ompA, gene 32), protein binding (XpLperhaps), or ribosome stalling (ermA, ermC), the initiation of decay at alternative sites in other messages could negate the effect of a 5' stabi lizer.
The only scope for modulation of mRNA stability by the 3' end is to alter its accessibility to exonuclease digestion. This could be achieved by endonuclease cleavage of the 3' stem-loop, by alternate folding of the mRNA, or potentially by altering interactions of the stem-loop with binding proteins. While such events occur, none are known to be regulated in response to specific signals. Instead, the few regulatory events that have been studied involve rate-determining endonucleolytic cleavages controlled by the 5' end of the message (Melefors and vonGabain, 1988; Emory and Belasco, 1990), and this seems likely to be the main site at which regulation of mRNA stability occurs.