Development of Novel Vaccines: Skills, Knowledge and by Şefik Ş. Alkan (auth.), Alexander von Gabain, Christoph

By Şefik Ş. Alkan (auth.), Alexander von Gabain, Christoph Klade (eds.)

“Development of novel vaccines” supplies an outline of the projects in easy examine resulting in the ultimate product – the vaccine and its functions, belonging to the main advanced biologics within the pharmaceutical box. unique from so much textbooks within the vaccine enviornment, the present factor makes a speciality of the translational element, specifically, how study effects will be remodeled into life-saving scientific interventions. each one bankruptcy of the booklet offers with one very important paradigm for the advance of novel vaccines, alongside the worth chain in the direction of the ultimate vaccine, and in addition, with the inevitable instruments required for this procedure. Contributions are ready by means of groups of scientists, all of whom are specialists within the box, such a lot of them anchored in biomedical organisations dedicated to translational tradition, thereby lighting fixtures the definite subject matters from assorted perspectives. This quantity is a needs to learn for researchers engaged in vaccine improvement and who actually need to determine their learn effects to turn into a product.

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Extra info for Development of Novel Vaccines: Skills, Knowledge and Translational Technologies

Sample text

None of the nine antigens induced the same high level of protection as the homologous M protein, but the efficacy was comparable in case of heterologous challenge. Since the M protein exists in >100 different serotypes, compiling a vaccine even with the most relevant M types is challenging. The concern about the involvement of M protein-specific antibodies in poststreptococcal sequelae and the risk of inducing serotype shift and vaccine escape strongly support the efforts toward a non-M protein-based vaccine for the prevention of pharyngitis and postinfectious complications.

It is a major challenge to predict the efficacy of a vaccine. A recent study used a systems biology approach to identify early gene “signatures” that predicted immune responses in humans vaccinated with yellow fever vaccine YF-17D (Querec et al. 2009). The study showed that vaccination induced genes that regulate innate sensing of the virus. Computational analyses identified a gene signature, including complement protein C1qB and eukaryotic translation initiation factor 2 alpha kinase 4, an orchestrator of the integrated stress response that correlated with and predicted YF-17D CD8 (þ) T-cell responses with up to 90% accuracy in an independent, blinded trial.

It is strongly recommended to replace the in silico analysis with the proteomic characterization of surface and secreted proteins, starting from a sufficiently large panel of strains. If properly carried out, this approach leads to the identification of no more than 30–40 sufficiently conserved antigens, which, being surface-associated and/or secreted, constitute the pool of proteins with the highest probability of being protective. Therefore, these are the proteins to be expressed and tested in the biological models.

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