By Mino R. Caira, Corina Ionescu
Drug Metabolism: present Concepts
Corina Ionescu and Mino R Caira
Drug Metabolism: present options presents a accomplished figuring out of the strategies that happen following ingestion of a medicinal agent or xenobiotic, with an emphasis at the an important position of metabolism (biotransformation). How a legitimate wisdom of those phenomena is included into the layout of powerful new drug applicants can also be defined. The simple textual content makes a speciality of options instead of extraneous info and is supported via many illustrated examples of biotransformations in addition to common references to present severe reports and articles highlighting the character of analysis pursuits during this shiny quarter of medicinal improvement. the ultimate subject on options for drug layout depends upon the heritage supplied by means of the remainder of the book.
The ebook contains chapters on
ADME (drug absorption, distribution, metabolism and removal)
Pathways of biotransformation (Phase I and section II metabolic reactions)
Enzymatic platforms fascinated about biotransformation
Induction and inhibition of drug-metabolising enzymes
Factors that impression drug biotransformation
The position of pharmacogenetics
Drug-drug interactions and adversarial reactions
Strategies for drug layout.
This booklet is very best as a complicated textual content for classes in drug metabolism for college students of drugs, pharmacy, pharmacology, biochemistry; and for classes in drug layout and drug supply for college students of medicinal chemistry. it's also applicable for pro seminars or classes that relate to the destiny of a drug within the physique, drug interactions, adversarial reactions and drug design.
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Additional resources for Drug Metabolism: Current Concepts
A feature highlighted there is the strong dependence of particular metabolic reactions on factors such as species-, tissue-, and sex-related differences. The phase I oxidative enzymes are almost exclusively localised in the endoplasmic reticulum (by contrast, most phase II enzymes being found predominantly in the cytoplasm). They differ markedly in structure and Pathways of biotransformation – phase I reactions 49 properties; among them, the most intensively studied both for drug and endogenous compound metabolism is the cytochrome P450.
2000. Absorption, distribution, metabolism and excretion of intravenously and dermally administered triethanolamine in mice. Food Chem Toxicol 38:1043-1051. 1 INTRODUCTION Drug metabolism is a complex and important part of biochemical pharmacology. The pharmacological activity of many drugs is reduced or nullified by enzymatic processes, and drug metabolism is one of the main mechanisms by which drugs may be inactivated. Metabolism, or the biotransformation of a drug, is the process whereby living organisms effect chemical changes to a molecule [1-8].
10. Ward PD, Tippin TK, Thakker DR. 2000. Enhancing paracellular permeability by modulating epithelial tight junctions. Pharm Sci Technol To 3: 346-358. 38 Chapter 1 11. Lennernas H. 2003. Intestinal drug absorption and bioavailability: Beyond involvement of single transport function. J Pharm Pharmacol 55:429-433. 12. Agoram B, Woltosz WS, Bolger MB. 2001. Predicting the impact of physiological and biochemical processes on oral drug bioavailability. Bulletin Technique Gattefosse 94: 41-65. 13. Levitt MD, Levitt DG.