Engineering the Genetic Code: Expanding the Amino Acid by Nediljko Budisa

By Nediljko Budisa

The power to introduce non-canonical amino acids in vivo has drastically extended the repertoire of obtainable proteins for uncomplicated examine and biotechnological application.
the following, the various equipment and techniques to include new or transformed amino acids are defined intimately, together with loads of functional suggestion for first-time clients of this robust technique.
Novel purposes in protein biochemistry, genomics, biotechnology and biomedicine made attainable by way of the growth of the genetic code are mentioned and various examples are given.
crucial studying for all molecular lifestyles scientists who are looking to remain forward of their examine.

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Additional resources for Engineering the Genetic Code: Expanding the Amino Acid Repertoire for the Design of Novel Proteins

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Nature 190, 576–581. , Carlton, B. , Guest, J. R. and Helinski, D. R. (1964). On the colinearity of gene structure and protein structure. Proceedings of the National Academy of Sciences of the USA 51, 226–272. Benzer, S. (1955). Fine structure of a genetic region in bacteriophage. Proceedings of the National Academy of Sciences of the USA 41, 344–354. Watson, J. , Hopkins, N. , Roberts, J. , Steitz, J. A. and Weiner, A. M. (1988). Molecular Biology of the Gene. Benjamin Cummings, Amsterdam. Nirenberg, M.

Although AARS catalyze the same basic reaction and share a common substrate (ATP) and Mg 2þ as cofactor, they have long been known to differ in their size, amino acid sequence and subunit structure. For example, their molecular weight is in the range between 51 (CysRS) and 384 kDa (AlaRS), their primary polypeptide structures can be composed from ‘‘only’’ 334 (TrpRS) to 1112 amino acids (PheRS), while their atomic crystal structures are mainly monomeric (a: Arg, Cys, Glu, Gln, Ile, Leu, Val) or dimeric (a2 : Met, Tyr, Trp, Asn, Asp, His, Lys, Pro, Ser, Thr).

B. and Cohen, G. N. (1957). Biosynthesis by Escherichia coli of active altered proteins containing selenium instead of sulfur. Biochimica et Biophysica Acta 26, 252–261. Hoagland, M. B. (1960). The References 24 25 26 27 28 29 30 31 32 33 Relationship of Nucleic Acid and Protein Synthesis as Revealed by Cell-free Systems. Academic Press, New York. Cohen, G. N. and Munier, R. (1959). Effects of structural analogues of amino acids on growth and synthesis of proteins and enzymes in Escherichia coli.

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