Epilepsy, Infantile Spasms, and Development Encephalopathy by Philip A. Schwartzkroin, Jong M. Rho (Eds.)

By Philip A. Schwartzkroin, Jong M. Rho (Eds.)

Epilepsy, childish Spasms, and Developmental Encephalopathy explores the character and bases of childish spasms - a big consultant of the catastrophic developmental seizure problems obvious in early youth. even supposing this subject has obtained huge cognizance as a medical ailment, the underlying pathogenesis of childish spasms is still poorly understood. the purpose isn't just to describe and label the medical phenomenology linked to childish spasms, yet really to paintings towards an realizing of the underlying mechanisms and of potent therapy thoughts. the result's a quantity with a excessive density of interesting principles that may be taken to the bedside or to the laboratory for extra study.Approaching the topic from an interdisciplinary point of view, this ebook integrates medical and uncomplicated technological know-how in its dialogue of childish spasms as consultant of a standard developmental mind illness. It additionally presents experimentally testable hypotheses to direct additional learn, and provides studies of the literature linked to steered underlying mechanisms.Epilepsy, childish Spasms, and Developmental Encephalopathy explores the character and bases of childish spasms - an enormous consultant of the catastrophic developmental seizure issues noticeable in early early life. even though this subject has bought enormous consciousness as a scientific sickness, the underlying pathogenesis of childish spasms continues to be poorly understood. the purpose isn't really just to describe and label the scientific phenomenology linked to childish spasms, yet quite to paintings towards an realizing of the underlying mechanisms and of potent remedy concepts. the result's a quantity with a excessive density of interesting rules that may be taken to the bedside or to the laboratory for additional examine.

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Additional resources for Epilepsy, Infantile Spasms, and Development Encephalopathy

Example text

Infantile spasms represent an age-specific syndrome. Given that infantile spasms are often symptomatic of an encephalopathic process during a discrete window of brain development, factors controlling neuronal excitability that are u n d e r developmental regulation might be important in the pathogenesis of infantile spasms. Maturational events involved in infantile spasms might be those responsible for specific features of the associated encephalopathy or mechanisms underlying the highly specific epileptic phenotype.

1999). A chronic focal epilepsy with mossy fiber sprouting follows recurrent seizures induced by intrahippocampal tetanus toxin injection in infant rats. Neuroscience 92(1), 73-82. Anderson, A. , Hrachovy, R. , and Swann,J. W. (1997). Increased susceptibility to tetanus toxin-induced seizures in immature rats. Epilepsy Res. 26, 433-442. , and Baram, T. Z. (1996). Developmental profile of messenger RNA for the corticotropin-releasing hormone receptor in the rat limbic system. Brain Res. Dev. Brain Res.

IV. Glucose PET in West Syndrome: New Insights into the Pathophysiology A. Cortical Abnormalities B. Activation of Brain Stem and Basal Ganglia on PET: Clue for Age-Dependent Seizure Generalization V. Implication of Serotonergic Mechanisms in the Pathogenesis of West Syndrome: PET Studies Supported by in Vitro Findings VI. Gabaergic Mechanisms and West Syndrome: GABAAReceptor Binding Studied by PET VII. Future Directions: New PET Tracers and the Need for an Animal Model Acknowledgments References Functional neuroimaging, especially positron emission tomography (PET) using various tracers, provided new insights into the pathophysiology of West syndrome in the past decade.

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