Essential Concepts in Toxicogenomics by Donna L. Mendrick (auth.), Donna L. Mendrick, William B.

By Donna L. Mendrick (auth.), Donna L. Mendrick, William B. Mattes (eds.)

The box of toxicogenomics has been starting to be speedy, but with speedy development comes the necessity to periodically think of the character of the sector. Essential innovations in Toxicogenomics collects experiences, opinion items and case stories from the major specialists during this dynamic box with a spotlight on its program to prescription drugs. subject matters lined comprise concerns that have an effect on the standard of toxicogenomics experiments, statistical ways to their info research, using such information to construct toxicogenomic versions, and the usage of genomics to spot biomarkers in the preclinical and medical arenas. even supposing now not within the average Methods in Molecular Biology™ sequence layout, this quantity keeps the practicality and usability of the hugely profitable series.

Informative and state of the art, Essential thoughts in Toxicogenomics is a perfect source for pharmaceutical businesses, chemical brands, toxicologists, and all who needs to hold up to date on development during this important and critical field.

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339, 900–905. 16. Kalivendi, S. , Konorev, E. , Vanamala, S. , Kaji, E. , and Kalyanaraman, B. (2005) Doxorubicin activates nuclear factor of activated T-lymphocytes and Fas ligand transcription: role of mitochondrial reactive oxygen species and calcium. Biochem. J. 389, 527–539. 17. , and Gianni, L. (2004) Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol. Rev. 56, 185–229. 18. Robert, J. (2007) Preclinical assessment of anthracycline cardiotoxicity in laboratory animals: Predictiveness and pitfalls.

And Zimmermann, J. (2002) Increasing throughput in lead optimization in vivo toxicity screens. Curr. Opin. Drug Discov. Dev. 5, 72–78. 42. , et al. (2005) Microarray analysis in human hepatocytes suggests a mechanism for hepatotoxicity induced by trovafloxacin. Hepatology 41, 177–186. 43. G. (2001) Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity. Toxicol. Lett. 120, 359–368. 44. , and Asahi, S. (2005) A toxicogenomic approach to druginduced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system.

Showed a significant correlation with expression profiles induced in the liver by a number of known hepatotoxicants (Fig. 4 and Color Plate 3). In addition, gene expression changes indicative of an oxidative stress response were observed after treatment with Cpd-001. Thus, in this example, there were a significant number of gene expression changes suggestive of hepatotoxicity despite the lack of histopathologic or clinical chemistry changes of toxicologic significance. Similar findings were reported for the drug felbamate (66).

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