By P. C. Huang
Genetic Engineering suggestions: fresh Developments
summary: Genetic Engineering options: contemporary advancements
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Additional resources for Genetic Engineering Techniques: Recent Developments
Although the structure of the DNA sequence is fairly rigid, that of the enzyme is flexible, its final conformation depending on the interaction between the subunits and the DNA sequence. In the model, the S subunit would bind to the two constant domains of the sequence along the narrow groove. This binding would be independent of the presence or absence of methylated adenines, but would be unstable by itself. AdoMet binding to the M (modification) subunits would lead to a conformational change in the enzyme, and the M subunits would go into the major groove.
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