Handbook of Experimental Pharmacology, Vol. 194: Sensory by Brendan J. Canning, Domenico Spina

By Brendan J. Canning, Domenico Spina

The purpose of this ebook is to supply a finished and modern assessment of the biology of sensory nerves. in accordance with the subject of the instruction manual sequence, an emphasis may be put on the activities of gear, transmitters and autacoids that start up or inhibit sensory nerve activation (through activities on ion channels and receptors at their peripheral terminals) or modulate the discharge or activities of the transmitters published from the important terminals of sensory nerves. according to vast supportive facts within the literature, it truly is our view that many ailments are characterized via changes in sensory nerve functionality (eg ache, heart problems, and migraine). it really is our trust that this ebook might be precise, because it will comprehensively hide the function of sensory nerves throughout many healing parts.

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Extra info for Handbook of Experimental Pharmacology, Vol. 194: Sensory Nerves

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For a detailed description of the anatomical organization of visceral afferents, see Ja¨nig and McLachlan (1987) and Sengupta and Gebhart (1994c,1998). The primary sensory afferents are pseudounipolar cells having central and peripheral axonal processes. The peripheral process innervating the visceral organ may have specialized endorgan-like pacinian corpuscles or intraganglionic laminar endings or free nerve endings with multiple parallel branches known as ‘‘intramuscular array fiber’’ (Berthoud et al.

Although the resultant effect is the same for neonatal stress and a neonatal noxious stimulus, it may or may not share the same neural pathways, neurotransmitters, and neuroendocrine systems. In addition, there could be differential cognitive processing in the brain for different experiences, which is still poorly understood. N. 1 Anatomical Distribution of Visceral Afferents We have come a long way in our understanding of the existence and contribution of visceral sensory afferents in regards to visceral sensation.

32 2 Behavioral Studies for Visceral Pain in Laboratory Animals . . . . . . . . . . . . 1 Inflammatory Model . . . . . . . . . . . . . . . . . . . . . . . . 2 Neonatal Maternal-Separation-Induced Stress Model . . . . . . . . . . . . 3 Neonatal Noxious- Stimulus-Induced Visceral Hyperalgesia Model . . . . . . . 36 3 Contribution of Sensory Afferents in Visceral Pain . . . . . . . . . . . . . . . 1 Anatomical Distribution of Visceral Afferents .

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