By Robert K., and Granner, Daryl K., and Mayes, Peter A. Murray
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Additional resources for Harper's Illustrated Biochemistry
How do the normal metal-trafficking, -sensing, and management processes differ between a baseline and an activated state of any given cell? In order to tackle these challenging questions, researchers use interrogation of the physiochemical mechanisms of the metalloregulatory proteins, metallochaperones, from a diverse array of species including Escherichia coli, Saccharomyces cerevisiae, Mus musculus, and Homo sapiens. 2 Understanding the Cellular Metallome The total intracellular concentration of essential metal ions is referred to as the metallome, a term coined twice in 2001: once to describe the profile of transition metal concentrations in E.
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Future work will be geared toward understanding the physiological advantage that such a distortion provides to the pathogen and perhaps the discovery of agents that selectively inhibit pathogen-specific metal acquisition processes. 79 More information highlighting advances in understanding of pathogenicity and immunology can be found in Metals in Bacterial Pathogenicity and Immunity. 7 Concluding Remarks The importance of inorganic chemistry is becoming better understood across the board within the biological community.