Harper's Illustrated Biochemistry by Robert K., and Granner, Daryl K., and Mayes, Peter A. Murray

By Robert K., and Granner, Daryl K., and Mayes, Peter A. Murray

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How do the normal metal-trafficking, -sensing, and management processes differ between a baseline and an activated state of any given cell? In order to tackle these challenging questions, researchers use interrogation of the physiochemical mechanisms of the metalloregulatory proteins, metallochaperones, from a diverse array of species including Escherichia coli, Saccharomyces cerevisiae, Mus musculus, and Homo sapiens. 2 Understanding the Cellular Metallome The total intracellular concentration of essential metal ions is referred to as the metallome, a term coined twice in 2001: once to describe the profile of transition metal concentrations in E.

V. Newman, D. B. , 2010, 206, 159. V. , 2011, 6, 716. , 2010, 6, 674. , 1998, 28, 1199. , 2000, 275, 3873. I. , 2008, 13, 271. , 2007, 367, 970. Munkelt, Arch. , 2005, 183, 9. , 2003, 27, 313. , 2006, 1763, 711. 53. R. Sladek, G. Rocheleau, J. Rung, C. Dina, L. Shen, D. Serre, P. Boutin, D. Vincent, A. Belisle, S. Hadjadj, B. Balkau, B. Heude, G. Charpentier, T. J. Hudson, A. Montpetit, A. V. Pshezhetsky, M. Prentki, B. I. Posner, D. J. Balding, D. Meyre, C. Polychronakos, and P. Froguel, Nature, 2007, 445, 881.

Future work will be geared toward understanding the physiological advantage that such a distortion provides to the pathogen and perhaps the discovery of agents that selectively inhibit pathogen-specific metal acquisition processes. 79 More information highlighting advances in understanding of pathogenicity and immunology can be found in Metals in Bacterial Pathogenicity and Immunity. 7 Concluding Remarks The importance of inorganic chemistry is becoming better understood across the board within the biological community.

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