HIV/AIDS Treatment Drugs (Drugs: the Straight Facts) by Brigid M. Kane

By Brigid M. Kane

A part of the wonderful medicinal drugs: The directly proof sequence, HIV/AIDS remedy medicines teaches younger grownup readers the main updated information regarding the medication used to struggle the AIDS epidemic at the present time. Chapters provide a uncomplicated heritage of the way those medicinal drugs have been constructed in the course of the conflict opposed to AIDS and speak about sorts of medicinal drugs intensive, in addition to how they paintings, and the way medical professionals create particular mixtures to enhance their effectiveness. Social and political matters in relation to AIDS in addition to attainable concepts for the way forward for AIDS remedy also are pointed out, together with the wish of 1 day making a vaccine. Charts, diagrams, and a trouble-free word list improve this well timed and correct booklet, enthusiastically instructed for public and college library collections.

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HIV/AIDS Treatment Drugs (Drugs: the Straight Facts)

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It may not sound glamorous, but the job is an essential step in the HIV life cycle. The cleavage of the large polyproteins occurs as newly assembled HIV viral particles are budding from an infected cell. If newly released virions contain uncleaved polyproteins (such virions are said to be immature), then they will be incapable of infecting susceptible cells. Hence, drugs that inhibit the cleavage of these proteins can save innumerable cells from becoming infected by HIV. The HIV protease inhibitors are largely responsible for taking antiretroviral therapy to the next level, for changing expectations, and raising hopes.

Therapeutic Targets, Strategies, and Challenges The first drugs used to treat AIDS patients were inhibitors of the HIV reverse transcriptase enzyme. Because daily treatment with one reverse transcriptase inhibitor drug (monotherapy) was effective only for a relatively short period of time, scientists decided to test the effectiveness of using two of these drugs simultaneously in combination or intermittently. The rationale was that lower doses of each drug would reduce the intolerable side effects while possibly putting more punch in the mix.

Efavirenz co-formulated with the nucleoside analogs tenofovir and emtricitabine is an all-in-one pill that has the added bonus of a convenient dosing schedule (once a day). Nevirapine, an alternative to efavirenz, carries a risk of serious, possibly life-threatening, rash and liver damage, particularly among patients with high CD4+ T cell counts. Delavirdine is the least effective of the NNRTI drugs and is not recommended for use in any initial therapeutic regimen. At this time, there are at least five NNRTI drug candidates in clinical testing, one of which is in late testing (phase III clinical trial).

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