IL-11 Receptor by Keith J.

By Keith J.

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A. (1987). The composition of the T cell receptor repertoire in nude mice. J. Immunol. 138, 3873–3876. Malmberg, K. J. (2004). Effective immunotherapy against cancer: A question of overcoming immune suppression and immune escape? Cancer Immunol. Immunother. 53, 879–892. , and Zeier, M. (2004). Malignancy in renal transplantation. J. Am. Soc. Nephrol. 15, 1582– 1588. , McBride, M. , Cherikh, W. , Spain, P. , Marks, W. , and Roza, A. M. (2002). Transplant tumor registry: Donor related malignancies.

Except for 15 tumors that existed in donors at the time of transplantation, 6 tumors were de novo donor-derived tumors that developed in transplanted hematogenous or lymphoid cells of the donor. , 2002). These de novo tumors could be activated by the use of immunosuppressive drugs in the recipient even though the de novo tumors also could have been inactivated by immune surveillance in the donor before transplantation. D. Nonimmunological Surveillance The concept of cancer immune surveillance has been formulated based on the hypothesis that cancer cells are recognized as “nonself” and capable of inducing a rejection reaction.

2000b) Street et al. (2001) Street et al. (2002) Shankaran et al. (2001) Kaplan et al. (1998) Smyth et al. (2000b) TCR, T cell receptor; IFN, interferon; Stat1, signal transducers and activators of transcription 1; RAG, recombinaseactivating gene; NKT, natural killer T; IFNGR, interferon γ receptor; CTL, cytotoxic T lymphocyte; NK, natural killer; MCA, methylcholantrene; TPA, 12-O-tetradecanoylphorbol-13-acetate; DMBA, 7,12-dimethylbenzanthracene 16 2. CANCER IMMUNOEDITING: FROM IMMUNE SURVEILLANCE TO IMMUNE ESCAPE induce the same biologic effects as IFN-γ in the cancer immunoediting process.

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