Immune Recognition and Evasion: Molecular Aspects of by L.H.T. Van Der Ploeg (Eds.)

By L.H.T. Van Der Ploeg (Eds.)

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Shown in Fig. 137). The response of control cells cultured under equivalent conditions but in the presence o f maximally stimulatory doses o f LPS (20 μg/ml) is also shown. Anti-la anti3 bodies stimulated uptake o f [ H ] t h y m i d i n e which approximated that seen in LPS-containing cultures in both magnitude and kinetics. Thus, anti-μ, ILr4, and anti-la provide all signals necessary for proliferation. W e then determined whether this combination of signals is sufficient to drive differentiation o f Β cells to b e c o m e antibody-secreting cells.

I. ( 1 9 8 9 ) . Hum. Hern, Immunol. 25, (1989). Cell 111. 32. Wraith, (Cambridge, D. ) 57, 709. H. , and Acha-Orbea, H. 5 Mimicry between HLAB27 and Bacteria: A Spurious Finding or the Link Connecting HLAB27 and Arthritogenic Bacteria? D W I G H T H. K O N O , * JIN-HAI C H E N , t ASAO N A K A Y A M A , t A N D DAVID T. Y. Y U f ^Division of Biology California Institute of Technology Pasadena, California 91125 and 1Department of Medicine University of California, Los Angeles Los Angeles, California 90024 INTRODUCTION The spondyloarthropathies are a heterogeneous group o f diseases that include ankylosing spondylitis (AS), Reiters syndrome (RS), and the arthropathies associated with psoriasis and inflammatory bowel diseases.

M o r d e s , J. P . , a n d L i k e , A . A . ( 1 9 8 5 ) . Annu. 18. T o d d , J. Α . , A c h a - O r b e a , H . , B e l l , J. L , C h a o , N . , F r o n e k , Z . , J a c o b , C . O . , M c D e r m o t t , K . B . , a n d E r l i c h , H . A . ( 1 9 8 8 ) . , 239, 487. Sinha, Α . Α . , T i m m e r m a n , L . , Steinman, Rev. Immunol. 3, 289. L . , and M c D e v i t t , H . O . (1988). Science 240, 1003. 19. T o d d , J. Α . , B e l l , J. L , a n d M c D e v i t t , H . O . ( 1 9 8 7 ) .

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