Immunoinformatics: Predicting Immunogenicity In Silico by Darren R. Flower (Editor)

By Darren R. Flower (Editor)

This quantity either engages the reader and gives a valid beginning for using immunoinformatics ideas in immunology and vaccinology. It addresses databases, HLA supertypes, MCH binding, and different houses of immune structures. The ebook comprises chapters written by means of leaders within the box and gives an organization historical past for someone operating in immunoinformatics in a single easy-to-use, insightful quantity.

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Extra resources for Immunoinformatics: Predicting Immunogenicity In Silico (Methods in Molecular Biology Vol 409)

Sample text

They are listed in the germline gene tables of the IMGT Repertoire. The IMGT Protein displays show the translated sequences of the alleles ∗ 01 of the functional or ORF genes (1,2). 4. NUMEROTATION concept: the IMGT unique numbering A uniform numbering system for IG and TR sequences of all species has been established to facilitate sequence comparison and cross-referencing between experiments from different laboratories whatever the antigen receptor (IG or TR), the chain type or the species (21,22).

CDR-IMGT regions (for a IG light kappa or lambda, or a TR alpha or gamma V-DOMAIN) are coloured as follows: CDR1-IMGT (blue), CDR2-IMGT (bright green) and CDR3-IMGT (dark green). (See Color Plate 1 following p. 5. ORIENTATION concept: orientation of genomic instances relative to each other The ORIENTATION concept allows to set up genomic orientation (for chromosome, locus, and gene) and DNA strand orientation. It is particularly useful in large genomic projects to localize a gene in a locus and/or a sequence (or a clone) in a contig or on a chromosome.

Access to all of the pages and tools is via the IMGT/HLA Database homepage (see Fig. 3). Fig. 3. The IMGT/HLA Database Homepage. The database homepage is the main access point to the online tools provided by the database.

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