Lipid Second Messengers by Andrew F. G. Quest, Daniel M. Raben, Robert M. Bell (auth.),

By Andrew F. G. Quest, Daniel M. Raben, Robert M. Bell (auth.), Robert M. Bell, John H. Exton, Stephen M. Prescott (eds.)

Lipids characteristically were considered as serving services: to shape mobile membranes and to function strength shops. over the past 20 years, a brand new function for lipids has taken middle level: lipids can act as signalling molecules. This publication bargains with various lipids which were proven to be messengers. best scientists discover all identified lipid sessions other than steroid hormones. Researchers and educators in biochemistry in addition to in molecular and mobile biology will delight in this volume.

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1988). Since PKC is a physiological target for DAGs, these findings support the hypothesis that nuclear association of PKC correlates with agonist-induced elevation of nuclear DAGs. Agonist-induced increases in nuclear DAG levels have indeed been reported. , 1992). EGF also increases nuclear DAG levels (D. M. Raben and M. Jarpe, unpublished observation). , 1992). , 1991). Taken together, the data clearly suggest a linkage between mitogen-induced nuclear lipid metabolism, PKC activation, and cellular proliferation.

Additional proteins whose function may be modulated by DAG or other lipid second messengers exist that contain similar cysteine-rich motifs. For instance, chimaerins which are implicated in the control of membrane-cytoskeleton interactions, the proto-oncogenes vav and raj, and DGK which is important for attenuation of DAG signals and lipid biosynthesis. Thus, cysteine-rich regions are emerging as a highly versatile motif, potentially involved in mediating regulation by several lipid second messengers in addition to DAG, such as LPA, PIP3, or ceramide.

1992; Hannun, 1994). Alternatively, increases in diglyceride may activate the ratedetermining enzyme in PC biosynthesis, CTP-phosphocholine cytidylyltransferase (Kent, 1990; Kolesnick and Herner, 1990), leading to a decrease in phosphorylcholine as a result of its accelerated conversion to CDP-choline. , 1990). , 1990). , 1991). , 1991). There are two factors that may complicate interpretations about phospholipid sources based solely on molecular species analyses. First, conclusions about parent phospholipids may be compromised if there is selective hydrolysis of phospholipids containing certain molecular species.

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