Matrix Metalloproteinase Inhibitors: Specificity of Binding by Viola Vargová, Marek Pytliak, Viola Mechírová (auth.), Satya

By Viola Vargová, Marek Pytliak, Viola Mechírová (auth.), Satya Prakash Gupta (eds.)

Matrix metalloproteinases (MMPs) are proteolytic enzymes which are excited about many physiological and pathological tactics. the sector of MMP learn is essential because of the implications of the exact paralogs in either human body structure and pathology. Over-activation of those enzymes leads to tissue degradation, generating a wide range of ailment techniques comparable to rheumatoid arthritis, osteoarthritis, tumor development and metastasis, a number of sclerosis, congestive center failure, and others. therefore MMP inhibitors are applicants for healing brokers to strive against a couple of illnesses.

The current ebook discusses the layout and improvement of alternative sessions of inhibitors of vital sessions of MMPs, akin to gelatinases and collagenases. The articles concentration particularly on structure-activity relationships of all sessions of compounds and on their modes of motion and specificity of binding with the receptors according to experimental and theoretical experiences. those experiences represent a worthy asset for all these interested by drug improvement.

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Am J Physiol Renal Physiol 281:309–317 Sanchez-Lopez R, Alexander CM, Behrendtsen O, Breathnach R, Werb Z (1993) Role of zinc binding and hemopexin domain encoded sequences in the substrate specificity of collagenase and stromelysin-2 by chimeric proteins. J Biol Chem 268:7238–7247 Sang Q-XA, Jin Y, Newcomer RG, Monroe SC, Fang X, Hurst DR, Lee S, Cao Q, Schwartz MA (2006) Matrix metalloproteinase inhibitors as prospective agents for the prevention and treatment of cardiovascular and neoplastic diseases.

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