Medical Biochemistry: Human Metabolism in Health and Disease by Miriam D. Rosenthal

By Miriam D. Rosenthal

This e-book includes clinically suitable biochemistry for scientific scholars. The chapters on ldl cholesterol are nice, and extra actual than different texts. I had hassle with biochemistry--study the pathways again and again, then learn the textual content, and it'll all make experience. additionally, the scientific parts of this ebook are very pragmatic. And the writing is obvious and the textual content concise. proper pathology for forums is roofed on the ends of chapters.

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A neutral pH optimum, bile salt-stimulated lipase, present in human milk but not in cow’s milk, contributes substantially to triacylglycerol hydrolysis in the intestine of breast-fed infants. 2 Hydrolysis of Phospholipids. Pancreatic phospholipase A2 is secreted as a zymogen (inactive proenzyme), which is activated by trypsin-catalyzed hydrolysis. Phospholipase A2 catalyzes the partial hydrolysis of both dietary phospholipids and the phosphatidylcholine secreted by the liver and contained in the bile.

For example, dicumarol inhibits catalysis involving vitamin K. Since many enzymes in the blood-clotting cascade are activated by y -carboxylation, dicumarol acts as an anticoagulant that reduces the risk of thrombus formation. In some cases, two different molecules may both be substrates for the same enzyme, with each acting as a competitive inhibitor of the metabolism of the other. One such example is alcohol dehydrogenase, which catalyzes the oxidation of both ethanol and methanol: + NAD+ + acetaldehyde + NADH + HS methanol + NAD' + formaldehyde + NADH + Ht ethanol Although methanol itself is intoxicating, it is the metabolites of methanol (formaldehyde and formic acid) that are responsible for the blindness and death that result from methanol poisoning.

2- 1 I), such as prothrombin and other proteins of the blood-clotting cascade, and osteocalcin, a major bone protein. Vitamin K undergoes oxidation during y -carboxylation reactions and is subsequently regenerated in 24 ENZYMES 0 II -~~c-cH,-cH,-c-c~~- 1- -OOC-cH,-CHz-COO- pzz FIGURE 2-10 Role of ascorbic acid in the hydroxylation of a prolyl residue in collagen. two reduction reactions catalyzed by vitamin K epoxide reductase and vitamin K reductase, respectively. 11 Not All Cofactors Are Derived from Vitamins.

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