By Pierre Tufféry, Catherine Etchebest (auth.), A. Pullman, J. Jortner, B. Pullman (eds.)
Gathering jointly a few of the most sensible specialists on the earth, the twenty seventh Jerusalem Symposium used to be dedicated to the subject matter of the modelling of biomolecular buildings and mechanisms. due to contemporary progress in either value and viewers, the papers contained during this quantity current an intensive evaluate of the prestige of the current wisdom during this box.
the most subject matters lined by means of this year's Symposium comprise nucleic acids and their interactions, proteins and their interplay, membranes and their interactions, enzymatic techniques and the pharmacological and clinical facets of those matters. Readers will enjoy the interdisciplinary process which supplies an intensive insurance of either theoretical and experimental advances.
Read Online or Download Modelling of Biomolecular Structures and Mechanisms: Proceedings of the Twenty-Seventh Jerusalem Symposium on Quantum Chemistry and Biochemistry Held in Jerusalem, Israel, May 23–26, 1994 PDF
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Additional info for Modelling of Biomolecular Structures and Mechanisms: Proceedings of the Twenty-Seventh Jerusalem Symposium on Quantum Chemistry and Biochemistry Held in Jerusalem, Israel, May 23–26, 1994
R. Lavery, H. Sklenar, K. Zakrzewska, and B. Pullman: J. Biomol. Struct. Dynam. 3, 989-1014 (1986). 29. R. Lavery, I. Parker, and J. Kendrick: J. Biomol. Struct. Dynam. 4, 443-461 (1986). 30. B. Hingerty, R. H. Richie, T. L. Ferrel, and J. E. Turner: Biopolymers 24, 427-439 (1985). 31. B. Hartmann, B. Malfoy, and R. Lavery: J. Mol. Bioi. 207, 433-444 (1985). 32. R. Lavery and K. Zakrzewska: in D. Beveridge, and R. ) Theoretical Chemistry and Molecular Biophysics. Vol. 1 DNA, Adenine Press, pp. 173-190 (1990).
That the M2 segment builds an a-helix is supported. Figure 4 shows the amino acid sequence in the 'unfolded-cylinder' representation. The important amino acids are facing the same direction (emphasized circles in Figure 4). Highly conserved amino acids (italicized characters in Figure 4) are facing either to the side or to the back side. Single point mutations of the hydrophilic amino acids which presumably point in the direction of the lipid membrane are found to have no measurable effect on ion flow [Villarroel, personal communication].
Neumann: Biochemistry 19, 3705-3711 (1980). 9. S. G. Cohen, H. Salih, M. Solomon, S. B. B. Cohen: Biochim. Biophysica Acta 997, 167-175 (1989). 10. C. Weise, H. J. Kreienkamp, R. Raba, A. Pedak, A. Aaviksaar, and F. Hucho: Embo J. 9, 38853888 (1990). 11. J. L. Sussman and I. Silman: Current Opinions in Structural Biology 2, 721-729 (1992). 12. J. L. Sussman, M. Harel, and I. Silman: in A. Pullman et al. ), Membrane Proteins, Structures, Interactions and Models, KIuwer Academic Publishers, Dordrecht pp.