Molecular, Genetic, and Nutritional Aspects of Major and by James F Collins

By James F Collins

Molecular, Genetic, and dietary elements of significant and hint Minerals is a different reference that offers a whole evaluation of the non-vitamin micronutrients, together with calcium, copper, iodine, iron, magnesium, manganese, molybdenum, phosphorus, potassium, selenium, sodium, and zinc.

In addition, the e-book covers the dietary and toxicological houses of nonessential minerals chromium, fluoride and boron, and silicon and vanadium, in addition to ultra-trace minerals and people without validated nutritional requirement for people. clients will locate in-depth chapters on every one crucial mineral and mineral metabolism, besides discussions of nutritional suggestions within the usa and round the world.

  • Presents the single clinical connection with hide all the nutritionally appropriate crucial significant and hint minerals
  • Provides a extensive introductory bankruptcy on every one mineral to offer readers worthy historical past and context
  • Clarifies the mobile and molecular points of every mineral and its genetic and genomic aspects
  • Includes insurance of all nutritionally proper minerals―essential significant hint minerals and ultra-trace minerals
  • Underscores the $64000 interactions among minerals so readers find out how metabolism of 1 mineral affects another

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Dis. Clin. North Am. 38, 1–11 vii. , 2008. Vitamin D gene regulation. J. ), Principles of Bone Biology. Elsevier-Academic Press, New York, NY, pp. 779–794. , 2012. Recent advances in our understanding of 1,25-dihydroxyvitamin D(3) regulation of intestinal calcium absorption. Arch. Biochem. Biophys. 523, 73–76. , 2012. Villin promoter-mediated transgenic expression of transient receptor potential cation channel, subfamily V, member 6 (TRPV6) increases intestinal calcium absorption in wild-type and vitamin D receptor knockout mice.

The current paradigm proposes that if this remodeling is occurring properly in the subcutaneous adipose tissue, then the energy excess can be handled without deleterious consequences at the cellular, tissue, and systemic level. , visceral) or other organs and tissues that become overloaded, thus altering their functions (from lipotoxicity; Bays, 2011). The increase in adipocyte size is accompanied by stress signaling and changes in the expression of genes involved in inflammation and lipid metabolism.

L Active intestinal calcium absorption independent of TRPV6 or calbindin-D9k can occur. l The epithelial calcium channel TRPV5 in the distal renal tubules has been reported to have a critical role in renal calcium reabsorption and is regulated by 1,25(OH)2D3, PTH, and FGF23. l Data from in vivo and in vitro studies suggest that the effects of 1,25(OH)2D3 in bone are diverse and that 1,25(OH)2D3 can affect bone formation and resorption. l Genome-wide studies have noted that actions of 1,25(OH)2D3 mediated by VDR are complex and involve coactivators, gene-specific transcription factors, and regulation of gene transcription at sites many kilobases from the transcription start site.

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