Oxygen Transport to Tissue XII by Hirosuke Kobayashi, Bernd Pelster, Johannes Piiper, Peter

By Hirosuke Kobayashi, Bernd Pelster, Johannes Piiper, Peter Scheid (auth.), Johannes Piiper, Thomas K. Goldstick, Michael Meyer (eds.)

The overseas Society on Oxygen shipping to Tissue (ISOTT) was once based in 1973 "to facilitate the trade of medical info between these attracted to any point of the shipping and/or usage of oxygen in tissues". Its participants span almost all disciplines, extending from a number of branches of medical drugs reminiscent of anesthesiology, ophthalmology and surgical procedure in the course of the simple scientific sciences of body structure and'biochemistry to so much branches of the actual sciences and engineering. The 17th annual assembly of ISOTT used to be held in 1989 for 4 days, from July 21 to 24, on the Max Planck Institute for Experimental medication and the adjacent college clinic (Klinikum), in Goettingen, Federal Republic of Germany. It attracted 147 lively registrants and nearly forty accompanying individuals. The very winning structure originated by way of Dr. Ian Longmuir in 1985, which include posters followed by means of an abbreviated oral precis, used to be endured with mild amendment. almost the entire displays applied this structure, with each one poster consultation preceded through a proper dialogue in which the presenter in short reviewed the poster aided through a couple of slides. All posters remained in position for the complete 4 days of the meeting.

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Wilke, C. , and Blanch, H. , 1987, "Effect of Dissolved Oxygen Concentration on Hybridoma Growth and Metabolism in Continuous Culture", Journal of Cellular Physiology, 132, 524530. Oberley, L. , Superoxide Dismutase and Cancer, 1982, in: "Superoxide Dismutase", Vol II, edited by Oberley, L. , CRC Press, Boca Raton, Florida. , CRC Press, Boca Raton, Florida. , Perez-Serrano, M. , 15 (3), 607-618. , Macmillan, J. , "Factors affecting Cell Growth and Monoclonal Antibody Production in Stirred Reactors", 1986, Journal of Immunological Method, 86, 53-59.

Piiper el at. Plenum Press, New York, 1990 21 niques, for a slightly different set of describing equations. Here, an analytical approximate solution is presented under the assumptions that: 1) axial diffusion is of negligible influence and 2) capillaries in each cross sectional plane can be represented ("seen" from outside the capillary) as point sources of oxygen. Facilitated diffusion by myoglobin can be incorporated under the additional assumption that myoglobin saturation is close to equilibrium with local oxygen partial pressure PO z and that myoglobin distribution is uniform.

Plenum Press, New York, 1990 47 content (and other constituents) in blood also influence extinction measurements for which must be corrected in order to obtain an accurate and reliable value of the SaOz and Hb-content. " _0""'; ·--·-- / ..... ~.... - "-'~' oxyhemoglobin 600 700 800 wavelength 900 [nm] Figure 1. Absorption coefficient of desoxyhemoglobin and oxyhemoglobin versus the measured wavelength. Assuming blood plasma to be transparant, the attenuation coefficient as: ,",0 = ao,ox cox lo,ox + ao,Dox c Dox 10,Dox + so,SaOZ,HI J1.

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